SGSK1349572

S/GSK1349572

Author: ApexBio

spu:

A4074

CAS:

1051375-16-6

purity:

0.9989

shortsummary:

HIV integrase inhibitor, novel and potent

pepstatin a protease inhibitor

Synonyms:

S/GSK1349572, GSK-1349572

9087-70-1 site

Formula:

C20H19F2N3O5

M.Wt:

419.4

Chemical Name:

(4R,12aS)-N-[(2,4-difluorophenyl)methyl]-7-hydroxy-4-methyl-6,8-dioxo-3,4,12,12a-tetrahydro-2H-pyrido[5,6]pyrazino[2,6-b][1,3]oxazine-9-carboxamide

SMILES:

CC1CCOC2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O

Solubility:

≥41.9 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH

Storage:

Store at -20°C

Physical Appearance:

A solid

DeliveryTime:

In stock

gw4064 fxr agonist

ShippingType:

Blue ice

description:

S/GSK1349572, also known as dolutegravir, is a novel and potent inhibitor of human immunodeficiency virus (HIV) integrase (IN) blocking the strand transfer of integration of the viral genome into the host cell’s DNA. It occupies the physical space in the IN active site of the intasome, contacts with the β4-α2 loop of the catalytic core domain, and enters into the pocket vacated by the displaced viral DNA through its extended linker region connecting the metal chelating core the halobenzyl group.  S/GSK1349572 exhibits potent anti-HIV activity in peripheral blood mononuclear cells (IC50 = 0.51 nM) in vitro and retains activity against raltegravir- and elvitegravir- resistant HIV.

related websites:

APExBIO Technology LLC is a premier provider of Small Molecule Inhibitors/Activators, Compound Libraries, Peptides, Assay Kits, Fluorescent Labels, Enzymes, Modified Nucleotides, mRNA synthesis and various tools for Molecular Biology. We carry a broad product line in over 1114 different research areas such as cancer, immunology, neurosciences, apoptosis and epigenetics etc. Based in USA (Houston, Texas), we have been serving the needs of customers across the world.